VDR is a gene that codes for a protein that acts as a receptor vitamin D, which regulates bone development and calcium absorption. A variant of the gene known as the rs2228570 (FokI polymorphism) is associated with lower bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the reciprocal and temporal pattern of off- and on- occupancy of the VDRE by two components, and it is influenced through chromosomal sites and binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes possess a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online storage facility for data and documents relevant to legal transactions, business or proceedings with restrictions on viewing, downloading or printing. It makes use of a central computer and an extranet which is a restricted access Internet connection, allowing https://www.gescheftmarketing.de/ users to login at specified times.
Investment bankers and companies involved in mergers and acquisitions are among the most common users of a VDR. They need a secure platform to share information with investors or potential buyers in a manner that is transparent and the process of due diligence may require large amounts of data. Life science companies also utilize VDRs to store everything from clinical trials results to HIPAA documentation.